ROBERT C. BARGER, M.S., R.PH.
To the editor: Dr. Lasagna's discussion (Ann Intern Med 85:619-621, 1976) of the poor performance of propoxyphene in single-dose trials and yet its remarkable success record may be in part explained by recently released Lilly promotional literature.
Waife and associates (1) have shown that a single dose of propoxyphene only reaches 40% of its steady-state effective level of 130 to 190 µg/ml. Codeine, acetaminophen, and aspirin reach a therapeutic level with a single dose. If two 65-mg capsules are taken or if propoxyphene is given every 6 h, therapeutic blood levels are obtained. The high rate of responses to propoxyphene
BARGER RC. Propoxyphene and Placebo. Ann Intern Med. ;86:506. doi: 10.7326/0003-4819-86-4-506_1
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Published: Ann Intern Med. 1977;86(4):506.
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