FREDERICK A. TOLLE, M.D.
To the editor: The natural course of angio-immunoblastic lymphadenopathy is not known. To date most patients have been treated with intensive cytotoxic chemotherapy; about one half of patients have died within 2 years of disease onset. Most of these deaths have been attributable to infection, mainly pulmonary (1, 2). Iseman, Schwarz, and Stanford (3) describe a patient with pulmonary infiltrates that pathologically are consistent with angio-immunoblastic lymphadenopathy. The pulmonary infiltrates disappear without therapy, while constitutional symptoms and pancytopenia develop insidiously. With high-dose prednisone therapy (80 mg/day), the symptoms abate and hematologic values improve. Because lymph nodes of patients before and
TOLLE FA. Angio-Immunoblastic Lymphadenopathy. Ann Intern Med. ;86:507–508. doi: 10.7326/0003-4819-86-4-507
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Published: Ann Intern Med. 1977;86(4):507-508.
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