P. J. PHILLIPS; R. W. PAIN; J. LLOYD
To the editor: Hypercalcaemia has recently been reported to be associated with increased serum lysozyme activity (1). Two mechanisms have been postulated: that the increased calcium concentration stimulates leukocytes to secrete lysozyme (1); and that bones release lysozyme and calcium together (2, 3). Whatever the mechanism, the finding of increased serum lysozyme activity in nine of sixteen hypercalcaemic patients (1) suggests that serum lysozyme estimation is unreliable as an index of myeloid proliferation in the presence of hypercalcaemia.
We were concerned by this possibility and measured serum lysozyme activity in 12 hypercalcaemic patients with nonhematologic malignancies (mainly breast and bronchogenic
PHILLIPS PJ, PAIN RW, LLOYD J. Lysozyme and Hypercalcaemia. Ann Intern Med. ;86:508. doi: 10.7326/0003-4819-86-4-508_1
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Published: Ann Intern Med. 1977;86(4):508.
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