J. L. MOAKE, M.D.; W. V. KAGELER, M.D.; P. L. CIMO, M.D.; R. W. BLAKELY, M.D.; R. D. ROSSEN, M.D.; W. HAESSE, M.D.
Two years after jejunal-ileal bypass surgery for obesity, a 25-year-old man developed intravascular hemolysis, thrombocytopenia, and neutropenia. The patient's erythrocytes were coated with complement components (C4/C3) and his serum induced complement-dependent immune lysis of chromium-51-labeled platelets. Serum [125I]-C1q binding activity (a measure of the presence of immune complexes) was increased, and serum C4 and C3 hemolytic titers were depressed. Immune complex-mediated complement activation apparently accounted for the blood cell destruction in this patient.
MOAKE JL, KAGELER WV, CIMO PL, BLAKELY RW, ROSSEN RD, HAESSE W. Intravascular Hemolysis, Thrombocytopenia, Leukopenia, and Circulating Immune Complexes after Jejunal-Ileal Bypass Surgery. Ann Intern Med. ;86:576–578. doi: 10.7326/0003-4819-86-5-576
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Published: Ann Intern Med. 1977;86(5):576-578.
Gastroenterology/Hepatology, Hematology/Oncology, Platelet Disorders.
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