NAGUIB A. SAMAAN, M.D., PH.D., F.R.C.P., F.A.C.P.; MICHAEL IBANEZ, M.D.; C. STRATTON HILL JR., M.D.
Sipple in 1961 (1) reported an endocrine tumor syndrome that is an association between thyroid carcinoma and pheochromocytoma. Later, it was ascertained that this combination of tumors represented a heritable entity that arose from the neuroectoderm. Weichert (2) reviewed the subject and developed a concept that the medullary carcinoma of the thyroid, pheochromocytoma, neurofibroma, and other associated tumors found in patients with multiple endocrine syndrome type 2 are forms of neuroectodermal dysplasia. Since these reports were published, a wealth of literature on the subject has accumulated but to our knowledge no report has been published on the association of medullary
SAMAAN NA, IBANEZ M, HILL CS. Medullary Carcinoma of the Thyroid and Astrocytoma. Ann Intern Med. ;86:585–586. doi: 10.7326/0003-4819-86-5-585
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Published: Ann Intern Med. 1977;86(5):585-586.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology, Neurology, Thyroid Disorders.
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