STEVEN D. REICH, M.D.
To the editor: The use of amphotericin B as a sensitizing agent during combination chemotherapy in human neoplasia has been reported by Presant, Klahr, and Santala (1). An implication of the lack of an important control population in this study deserves comment.
The commercial preparation of amphotericin B, Fungizone® (E. R. Squibb, Princeton, New Jersey), is prepared with 41 mg of sodium deoxycholate to every 50 mg of amphotericin B. The deoxycholate is used to form a colloidal dispersion because crystalline amphotericin B is insoluble in water. Both amphotericin B and deoxycholate have cell-membrane altering effects that can increase the
REICH SD. Deoxycholate or Amphotericin B in Chemotherapy Sensitization. Ann Intern Med. 1977;86:656–657. doi: 10.7326/0003-4819-86-5-656
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Published: Ann Intern Med. 1977;86(5):656-657.
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