To the editor: The discussion in the masterly paper by Fauci, Johnson, and Wolff on the radiotherapy of the idiopathic midline granuloma in the July issue (2) raises several important points.
The entity of the lethal or midline granuloma has been doubted. I agree with Fauci and colleagues that "this is an entity characterized by destructive lesions localised to the upper respiratory tract that is unrelated to detectable tumours and probably caused by a fulminant inflammatory response to an unknown antigen." The validity of this entity has, in fact, been confirmed by the authors proposing an alternative terminology.
I. FRIEDMANN. Midline Granuloma. Ann Intern Med. 1977;86:663. doi: 10.7326/0003-4819-86-5-663_1
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Published: Ann Intern Med. 1977;86(5):663.
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