J. L. GABRILOVE, M.D.; G. L. NICOLIS, M.D., PH.D.
To the editor: From their study of Nelson's syndrome Moore and colleagues (1) reported nine patients with the disorder out of 120 patients treated for Cushing's syndrome. Of these nine only two had received prior pituitary irradiation; one having received 3000 rad, the other 5000. They cite a case from Salassa's and associates' series of pituitary tumors in patients with Cushing's syndrome who was reported without comment to have developed a pituitary tumor subsequent to pituitary irradiation with 2400 rad and bilateral subtotal adrenalectomy. Most radiotherapists would consider that dosages of 2400 to 3000 rad to the pituitary at the
GABRILOVE JL, NICOLIS GL. Nelson's Syndrome. Ann Intern Med. ;86:665. doi: 10.7326/0003-4819-86-5-665_1
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Published: Ann Intern Med. 1977;86(5):665.
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