HENRY R. LESESNE, M.D.; JOHN E. MORGAN, M.D.; PHILIP M. BLATT, M.D.; WILLIAM P. WEBSTER, D.D.S.; HAROLD R. ROBERTS, M.D.
Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia A who had the persistence of abnormal liver-function tests for at least 6 months, are described. Three patients had chronic active hepatitis, and three had chronic persistent hepatitis. No complications were encountered as a result of the biopsy procedure. These results suggest that percutaneous liver biopsy should be considered in patients with hemophilia A with continuously abnormal liver-function tests to establish a histologic diagnosis and to guide further therapy.
HENRY R. LESESNE, JOHN E. MORGAN, PHILIP M. BLATT, WILLIAM P. WEBSTER, HAROLD R. ROBERTS. Liver Biopsy in Hemophilia A. Ann Intern Med. 1977;86:703–707. doi: 10.7326/0003-4819-86-6-703
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Published: Ann Intern Med. 1977;86(6):703-707.
Coagulopathies, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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