J. F. MALONE, PH.D.; M. J. CULLEN, M.B.
To the editor: McDougall and Greig (1) recently presented their results of 125I treatment of Graves' disease. The data are sufficient to allow the incidence of hypothyroidism after this mode of therapy to be examined to see if it conforms to the two-mechanism hypothesis postulated for 131I (2). With 131I early incidence, 2 years after therapy is linearly related to dose and is thought to be induced directly by radiobiological events. Late incidence, after more than 2 years, is relatively dose independent and hence is thought to be related to some fundamental biological property of the thyroid such as the
MALONE JF, CULLEN MJ. Hypothyroidism after 125I Therapy. Ann Intern Med. ;86:823–824. doi: 10.7326/0003-4819-86-6-823
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Published: Ann Intern Med. 1977;86(6):823-824.
Endocrine and Metabolism, Thyroid Disorders.
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