EDWARD CHIRITO, M.D.
To the editor: The review article "Hematologic Aspects of Systemic Lupus Erythematosus" by Budman and Steinberg (Ann Intern Med 86:220-229, 1977) omits mention of the bone marrow as a target organ in the disease. Rosen and associates (1) have reported five patients with the bone-marrow morphologic features of myelofibrosis in association with the lupus erythematosus cell phenomenon. In addition, all five had antinuclear antibodies in the serum, and two had a positive direct antiglobulin reaction (Coombs' Test). Clinically, four were female, four had unexplained fever, and two arthralgia. Only one patient was under age 50 and none manifested the classical
CHIRITO E. Bone Marrow in Lupus Erythematosus. Ann Intern Med. ;86:831–832. doi: 10.7326/0003-4819-86-6-831_2
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Published: Ann Intern Med. 1977;86(6):831-832.
Lupus Erythematosus, Rheumatology.
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