JOHN D. BRUNZELL, M.D., F.A.C.P.; EDWIN L. BIERMAN, M.D., F.A.C.P.
Plasma triglyceride levels have been correlated with insulin levels in both normal populations and in patients with endogenous hypertriglyceridemia (1). As a result of this reproducible significant association, it has been suggested that hyperinsulinism might be causally related to endogenous hypertriglyceridemia (2).
It has now been established that "endogenous hypertriglyceridemia" describes a heterogenous group of primary familial and sporadic disorders. Recently two common forms of monogenic hypertriglyceridemia have been described: "pure" monogenic familial hypertriglyceridemia, in which the hypertriglyceridemic propositus comes from a family in which all affected relatives have isolated hypertriglyceridemia; and familial combined hyperlipidemia, in which the hypertriglyceridemic propositus
BRUNZELL JD, BIERMAN EL. Plasma Triglyceride and Insulin Levels in Familial Hypertriglyceridemia. Ann Intern Med. ;87:198–199. doi: 10.7326/0003-4819-87-2-198
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Published: Ann Intern Med. 1977;87(2):198-199.
Cardiology, Coronary Risk Factors, Diabetes, Dyslipidemia, Endocrine and Metabolism.
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