WAYMAN D. MERRILL, M.D.; J. RANDOLPH FARRIS, M.D.; OTIS ROUNDS, M.D.
To the editor: We wish to report having identified hepatitis antigen in a pleural effusion complicating a case of hepatitis. Pleural effusion, as a complication of hepatitis, was first reported in 1971 (1). Later, a series of patients with hepatitis was reported in which it was again shown that hepatitis may rarely be complicated and even preceded by a pleural effusion (2). Hepatitis antigen has been reported in urine, saliva, bile, feces, semen, breast milk, tears, vaginal secretions, and sneeze droplets, but never before in pleural fluid (3).
A 40-year-old Latin American man presented with a complaint of anorexia and
MERRILL WD, FARRIS JR, ROUNDS O. Hepatitis Antigen in Pleural Fluid. Ann Intern Med. ;87:247. doi: 10.7326/0003-4819-87-2-247_1
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Published: Ann Intern Med. 1977;87(2):247.
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