JOHN S. PENTA, PH.D.; DANIEL D. VON HOFF, M.D.; FRANCO M. MUGGIA, M.D.
To the editor: Recently, reports have appeared that describe hepatotoxicity in patients with acute leukemia after combination chemotherapy with antimetabolites and anthracycline antibiotics (1, 2). Over the past 9 months since Dr. J. Lawrence Naiman (St. Christopher's Hospital for Children, Philadelphia, Pennsylvania) first brought to our attention four cases of possible hepatotoxicity after daunorubicin therapy, we have received a total of 13 reports on leukemia patients with hepatotoxicity after administration of 6-thioguanine or cytarabine (cytosine arabinoside), or both, in combination with the anthracycline antibiotic daunorubicin (see Table 1).
Most of the patients were in remission at the onset of hepatic
PENTA JS, VON HOFF DD, MUGGIA FM. Hepatotoxicity of Combination Chemotherapy for Acute Myelocytic Leukemia. Ann Intern Med. ;87:247–248. doi: 10.7326/0003-4819-87-2-247_2
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Published: Ann Intern Med. 1977;87(2):247-248.
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