M. ELAINE EYSTER, M.D., F.A.C.P.; HERBERT S. BOWMAN, M.D., F.A.C.P.; JUDY N. HAVERSTICK, R.N.
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To the editor: In a 15-month period during which time 4 700 000 units of factor VIII were used by 70 hemophiliacs known to us, fifteen adverse reactions were reported. Excluding surgical use, this represents an average of 40 000 factor VIII units per patient treated per year. Ten reactions occurred in 53 patients (19%) receiving freeze-dried concentrates; five occurred in 17 patients (29%) receiving cryoprecipitate.
Anaphylactoid reactions consisting of severe bronchospasm, dyspnea, and substernal pain or hypotension, or both, occurred in five patients, four of whom received concentrates and one of whom received cryoprecipitate. All responded promptly to adrenalin
EYSTER ME, BOWMAN HS, HAVERSTICK JN. Adverse Reactions to Factor VIII Infusions. Ann Intern Med. ;87:248. doi: 10.7326/0003-4819-87-2-248_1
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Published: Ann Intern Med. 1977;87(2):248.
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