To the editor: In the March 1977 issue a letter by Oster (1) stated that folic acid has been neglected for its xanthine oxidase-inhibiting effect by the medical profession. Dr. Oster further claimed that he has used this drug in 180 patients without any untoward effects.
I was fascinated by Dr. Oster's claims of a nontoxic, potent xanthine oxidase inhibitor. I have been unable, however, to find any documentation in the literature from controlled studies that it is effective as a xanthine oxidase inhibitor in treating hyperuricemia. The data presented by Dr. Oster in his original work (2) cannot be
PLACHETKA J. Xanthine Oxidase and Folic Acid. Ann Intern Med. ;87:252–253. doi: 10.7326/0003-4819-87-2-252_2
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Published: Ann Intern Med. 1977;87(2):252-253.
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