MARVIN C. GERSHENGORN, M.D.; MICHAEL R. McCLUNG, M.D.; ELIZABETH W. CHU, M.D.; THOMAS A. S. HANSON, M.D.; BRUCE D. WEINTRAUB, M.D.; JACOB ROBBINS, M.D.
Fifty consecutive patients were studied to assess the utility of fine-needle aspiration cytology for the diagnosis of hypofunctioning thyroid nodules. In two patients, cysts were evacuated and did not recur. Thirty-three patients underwent excisional biopsy; the aspiration biopsy result was not a criterion for surgery. Satisfactory aspiration specimens were obtained in 32 patients (97%). The diagnosis in nine aspiration specimens was malignant; of these seven (78%) were correct and there was one false-positive and one occult carcinoma unrelated to the clinically detected nodule. Five aspirations showed suspected malignancy; of these, two were carcinoma, one was an occult carcinoma, and two were benign. Eighteen aspirations were interpreted as benign; of these, 17 (94%) were correct and the one false-negative diagnosis was a well-differentiated follicular carcinoma. The procedure is useful in assessing the need for surgery in high-risk patients and in selecting patients for thyroid-suppression therapy.
GERSHENGORN MC, McCLUNG MR, CHU EW, HANSON TAS, WEINTRAUB BD, ROBBINS J. Fine-Needle Aspiration Cytology in the Preoperative Diagnosis of Thyroid Nodules. Ann Intern Med. 1977;87:265–269. doi: 10.7326/0003-4819-87-3-265
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Published: Ann Intern Med. 1977;87(3):265-269.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology, Thyroid Disorders.
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