MICHAEL J. WEAVER
To the editor: The recently published recommendations for the management of rabies emphasized the importance of local wound care, consisting of a thorough scrubbing with soap and water (1).
This scrubbing should be followed by a thorough rinsing with water or saline to remove all traces of the soap, then followed by another scrubbing with a quaternary ammonium compound such as 1% benzalkonium chloride (Zephiran®) (2, 3). The rationale is that the quaternary ammonium compounds inactivate the rabies virus invitro (4), and, when injected locally, protect animals from infection from experimental rabies virus exposure (5). The rinsing is needed because
WEAVER MJ. Rabies and Wound Care. Ann Intern Med. ;87:381. doi: 10.7326/0003-4819-87-3-381_1
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Published: Ann Intern Med. 1977;87(3):381.
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