LAWRENCE J. BRANDT, M.D.
Formication (Latin: formica, ant), a variant of pruritus or paresthesia in which there is the sensation of ants crawling over the skin, was recently observed during azathioprine (Imuran®; Burroughs Wellcome Co.; Research Triangle Park; North Carolina) therapy in a patient with chronic active liver disease, and represents a previously undescribed complication of that drug.
The patient, a 56-year-old white woman with chronic membranous glomerulonephritis and renal failure, developed abnormal liver function test results: serum glutamic oxalacetic transaminase (SGOT), 155 IU/litre; serum glutamic-pyruvic transaminase (SGPT), 271 IU/litre; alkaline phosphatase (AP), 131 IU/litre; bilirubin, 1 mg/dl; and a positive hepatitis B surface
BRANDT LJ. Formication and Azathioprine Therapy. Ann Intern Med. ;87:458. doi: 10.7326/0003-4819-87-4-458
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Published: Ann Intern Med. 1977;87(4):458.
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