CHARLES M. PETERSON, M.D., F.A.C.P.; ROBERT L. JONES, M.D.
Although diabetes mellitus has been recognized as a clinical syndrome since the Ebers Papyrus, and the ideal therapy has been available in the form of replacement of the missing hormone since the 1920s, the disease continues to challenge the clinician through its almost ubiquitous sequelae. Hyperglycemia and ketosis are generally accepted as being the direct result of insulin deficiency. The causes of other sequelae are not as clear; complications often arise during long periods of time and may be due to insulinopenia, hyperglycemia, or other factors acting alone or in concert.
With the advent of radioimmunoassays, measurements of hormone reserve
PETERSON CM, JONES RL. Minor Hemoglobins, Diabetic "Control," and Diseases of Postsynthetic Protein Modification. Ann Intern Med. ;87:489–491. doi: 10.7326/0003-4819-87-4-489
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Published: Ann Intern Med. 1977;87(4):489-491.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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