ROBERT I. LEVY, M.D.; JOEL MORGANROTH, M.D.
Familial hyperlipoproteinemia was discovered through one of its secondary and inconsistent manifestations, deposits of lipids in skin and tendons, called xanthomatosis. As early as 1873, however, it was suggested that xanthomas might arise from hyperlipidemia, a supposition reinforced by histologic and chemical analyses of xanthomatous lesions in man and experiments in animals (1).
Gofman and colleagues (2) laid the foundation for the study of hyperlipidemia based on lipoprotein analyses. In 1954, using analytical ultracentrifugation they provided the first clear-cut separation by lipoprotein analyses of what they then called "xanthoma tuberosum" from "xanthoma tendinosum." The patient with "xanthoma tendinosum" (now known
LEVY RI, MORGANROTH J. Familial Type III Hyperlipoproteinemia. Ann Intern Med. ;87:625–628. doi: 10.7326/0003-4819-87-5-625
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Published: Ann Intern Med. 1977;87(5):625-628.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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