ROBERT A. MCDONALD, M.D.; NICHOLAS LOWE, M.B., M.R.C.P.
To the editor: Subcutaneous nodular fat necrosis associated with pancreatic diseases is an entity distinct from other forms of panniculitis. Rubinstein and associates (1) have further associated this cutaneous marker of pancreatitis with their finding of alpha1-antitrypsin deficiency in two patients. We believe, however, that their patients had clinical features of nodular fat necrosis of pancreatic disease rather than relapsing febrile nonsuppurative panniculitis (Weber-Christian disease).
Their patients developed the classic subcutaneous nodules on the legs and trunk that occasionally drained an odorless fluid. At autopsy panniculitis with fat necrosis was revealed. Szymanski and Bluefarb (2) reported five cases of nodular
MCDONALD RA, LOWE N. Panniculitis and Pancreatic Disease. Ann Intern Med. ;87:634–635. doi: 10.7326/0003-4819-87-5-634_3
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Published: Ann Intern Med. 1977;87(5):634-635.
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