FRED J. SCHIFFMAN, M.D.; ROBERT L. SCHIFFMAN, M.D.; ROBERT M. ROSA, M.D.
To the editor: The occurrence of hypokalemia with the blast crisis of acute myeloid leukemia has been described by Mir and co-workers (1a), and accounts of hypokalemia in other leukemic states have been reported by correspondents to Annals of Internal Medicine (1b, 1c). A recent report (2) in the pediatric literature describing eight cases shows that this phenomenon is not confined to adult patients with leukemia.
Although the mechanisms responsible for the development of hypokalemia have not been fully delineated, current evidence suggests that it results from renal potassium wasting or intracellular movement of potassium. Some hypokalemic leukemic patients manifest
SCHIFFMAN FJ, SCHIFFMAN RL, ROSA RM. Cellular Proliferation and Hypokalemia. Ann Intern Med. ;87:635–636. doi: 10.7326/0003-4819-87-5-635_2
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Published: Ann Intern Med. 1977;87(5):635-636.
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