I. HOLLÓ, M.D., D. MED. SCI.; J. SZÜCS, M.D.; M. BOROSS; F. SZALAY, M.D.
To the editor: We have read with great interest the excellent review of Thomson and Frame, "Involutional Osteopenia: Current Concepts" (Ann Intern Med 85:789-803, 1976). We wish to describe some of our findings and our hypothesis on the pathogenesis of postmenopausal osteoporosis.
1. In accord with the findings of Urist and Vincent we have found that urinary excretion of androgen metabolites is lower in patients with postmenopausal osteoporosis than in matched control subjects (1).
2. Conjugated dehydroepiandrosterone in the plasma of osteoporotic patients is significantly decreased (2).
3. The decreased calcitonin sensitivity in male rats after castration is well known;
HOLLÓ I, SZÜCS J, BOROSS M, SZALAY F. Osteopenia. Ann Intern Med. ;87:637. doi: 10.7326/0003-4819-87-5-637_1
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Published: Ann Intern Med. 1977;87(5):637.
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