PAUL P. VANARSDEL JR., M.D.
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To the editor: I wish to make a correction in our paper in the July 1977 issue, "Drug Therapy in the Management of Asthma" (Ann Intern Med 87:68-74, 1977). In the paragraph on inhaled glucosteroids (p. 72) we stated that lipid-soluble steroids are poorly absorbed when swallowed. It is true that they do not reach the systemic circulation to a notable degree. However, the probable mechanism is that the sparingly soluble steroid is slowly absorbed, which allows the liver to convert most of the drug to pharmacologically inactive polar metabolites. This is supported for beclomethasone by the work of Martin,
PAUL P. VANARSDEL. Correction: Drug Treatment of Asthma. Ann Intern Med. 1977;87:638. doi: 10.7326/0003-4819-87-5-638_1
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Published: Ann Intern Med. 1977;87(5):638.
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