WILLIAM A. CORNELIS, PHARM.D.
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To the editor: The article by Bennett and co-authors (Ann Intern Med 86:754-783, 1977) provides an exhaustive literature review of drug dosing in the presence of renal failure. However, the paper contains two erroneous statements.
The authors state that any drug dose used with normal renal function would need to be divided by the ratio of the normal half-life to the observed biological (renally impaired) half-life to find the dose in renal failure. They further state that any interval between drug doses used in patients with normal renal function would be multiplied by the ratio of the normal half-life to
CORNELIS WA. Correction: Drugs and Renal Failure. Ann Intern Med. ;87:638. doi: 10.7326/0003-4819-87-5-638_2
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Published: Ann Intern Med. 1977;87(5):638.
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