DAVID T. KIANG, M.D., Ph.D.; BJ. KENNEDY, M.D.
Fifty-nine postmenopausal women with advanced breast cancer were treated with tamoxifen (antiestrogen), 20 mg orally twice a day for at least 2 months. They had been previously treated with other types of hormonal therapy or intensive chemotherapies, or both. Nineteen of the 59 patients (32%) had either a complete response (seven patients) or partial response (12 patients). The median duration of response was 9 + months. Tumors containing estrogen receptors and those that responded to previous hormonal manipulation tended to respond to tamoxifen (60% and 69%, respectively). Patients with receptor-negative tumor or with a history of failure of previous hormonal treatments did not respond to tamoxifen therapy. Tamoxifen is effective against advanced breast cancer. Side effects of the treatment were mild.
KIANG DT, KENNEDY B. Tamoxifen (Antiestrogen) Therapy in Advanced Breast Cancer. Ann Intern Med. ;87:687–690. doi: 10.7326/0003-4819-87-6-687
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Published: Ann Intern Med. 1977;87(6):687-690.
Breast Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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