JACQUES LeLORIER, M.D., Ph.D., F.R.C.P.(C); DENIS GRENON; YVES LATOUR, M.D., F.R.C.P.(C); GILLES CAILLÉ, Ph.D.; GUY DUMONT, M.D., F.R.C.P.(C); ANDRÉ BROSSEAU, M.D.; ALAIN SOLIGNAC, M.D.
The kinetics of the elimination of lidocaine upon discontinuation of lidocaine infusions lasting more than 24 h were studied in 12 patients with uncomplicated myocardial infarctions. In this group of patients the mean half-life of the elimination phase was found to be 3.22 h. This is significantly different from the half-life of 100 min that has been reported after bolus injections or infusions lasting less than 12 h. This longer half-life should be taken into consideration in estimating the duration of toxicity and the rate of administration of the drug during and after intravenous infusions lasting 24 h or more.
LeLORIER J, GRENON D, LATOUR Y, CAILLÉ G, DUMONT G, BROSSEAU A, et al. Pharmacokinetics of Lidocaine after Prolonged Intravenous Infusions in Uncomplicated Myocardial Infarction. Ann Intern Med. ;87:700–702. doi: 10.7326/0003-4819-87-6-700
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Published: Ann Intern Med. 1977;87(6):700-702.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine.
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