ANDREW F. IPPOLITI, M.D.
Features of the Zollinger-Ellison syndrome (gastrinoma) include peptic ulcer disease, basal acid hypersecretion, and fasting hypergastrinemia. Its diagnosis is strongly supported by a serum gastrin concentration above 500 pg/ml in the absence of achlorhydria or renal failure. Such marked elevations of serum gastrin are not present in all gastrinoma patients, however. About 40% will have a fasting gastrin concentration of 100 to 500 pg/ml, whereas about 10% of ulcer patients without evidence of gastrinoma have fasting gastrin concentrations in that range. Therapy for ordinary peptic ulcer differs from that for the Zollinger-Ellison syndrome medically—short-term antacid or Cimetidine treatment rather than
IPPOLITI AF. Zollinger-Ellison Syndrome: Provocative Diagnostic Tests. Ann Intern Med. ;87:787–788. doi: 10.7326/0003-4819-87-6-787
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Published: Ann Intern Med. 1977;87(6):787-788.
Endocrine and Metabolism, Endocrine Cancer, Gastroenterology/Hepatology, Hematology/Oncology, Peptic Disease.
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