WILLIAM W. MCGUIRE, M.D.
To the editor: Dr. Byrd and associates (Ann Intern Med 86:799-802, 1977) have called attention to several important issues in the modern-day therapy of pulmonary tuberculosis. Of particular importance is the prevalence of isoniazid resistance in patients contracting disease in Southeast Asia, and the need for alternate therapy under these circumstances.
However, a critical and yet unanswered problem is how to approach the patient whose tuberculin skin test conversion occurs in Southeast Asia. Although isoniazid prophylaxis is advocated in certain well-defined groups by current standards, these standards do not take into account possible isoniazid resistance of the infecting tubercle bacillus
MCGUIRE WW. Tuberculosis Chemoprophylaxis. Ann Intern Med. ;87:792–793. doi: 10.7326/0003-4819-87-6-792_2
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Published: Ann Intern Med. 1977;87(6):792-793.
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