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In 1936 there appeared a Letter to the Editors in Nature in which H. Selye of McGill University described what seemed to be a nonspecific adaptive response to the injurious effects of a wide range of agents, including exercise, cold, drug intoxication, trauma and spinal shock. Today Hans Selye is both a great authority on stress and the foremost pioneer of stress research, much as Billroth and Harvey Cushing were the pioneers of modern surgery and neurosurgery.
Working in the intervening years at the Institute de Médecine et de Chirurgie expérimentales of the University of Montreal of which he ultimately
Stress in Health and Disease.. Ann Intern Med. ;87:799. doi: 10.7326/0003-4819-87-6-799_1
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Published: Ann Intern Med. 1977;87(6):799.
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