PAUL Y. HOLOYE, M.D.; MARIO A. LUNA, M.D.; BRUCE MacKAY, M.D.; CARLOS W. M. BEDROSSIAN, M.D.
Three patients developed radiologic and functional pulmonary changes after bleomycin therapy similar to ones previously associated with administration of this drug. However, biopsy specimens showed a pattern consistent with hypersensitivity pneumonitis rather than the interstitial pneumonia usually reported in bleomycin pulmonary toxicity. There was a patchy eosinophilic infiltrate surrounding small airways and distal air spaces, but no immune deposits were noted by ultrastructure or immunofluorescence using conventional techniques and a specific antibody against bleomycin. Two of the patients had peripheral eosinophilia of 12% and 16%. All three patients showed considerable improvement on chest roentgenogram after corticosteroid treatment. Our findings are consistent with the view that bleomycin hypersensitivity pneumonitis has a different pathogenesis than bleomycin interstitial pneumonitis. Its recognition as a separate entity seems warranted because of the favorable response to steroid therapy.
PAUL Y. HOLOYE, MARIO A. LUNA, BRUCE MacKAY, CARLOS W. M. BEDROSSIAN. Bleomycin Hypersensitivity Pneumonitis. Ann Intern Med. 1978;88:47–49. doi: 10.7326/0003-4819-88-1-47
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Published: Ann Intern Med. 1978;88(1):47-49.
Interstitial Lung Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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