ROBERT D. OKADA, M.D.; W. DAVID HAGER, M.D.; FRANK I. MARCUS, M.D.; DONALD PERRIER, PH.D.; PENELOPE GRAVES, PH.D.
To the editor: Various published nomograms attempt to use serum creatinine to predict a digoxin dosage that will be in the therapeutic, but less than the toxic, range in patients with decreased renal function (1, 2). We recently studied a patient whose measured pharmacokinetic parameters of digoxin deviated considerably from those predicted from available nomograms.
A 75-year-old euthyroid white man received digoxin for prophylaxis of paroxysmal atrial tachycardia. He was admitted to the hospital with symptoms of digoxin toxicity and with a serum digoxin level of 4.6 ng/ml. Despite a serum creatinine of 1.1 mg/ml, his serum digoxin level fell
OKADA RD, HAGER WD, MARCUS FI, PERRIER D, GRAVES P. Predicting Digoxin Dosage from Creatinine Clearance. Ann Intern Med. ;88:133. doi: 10.7326/0003-4819-88-1-133_1
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Published: Ann Intern Med. 1978;88(1):133.
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