ANDREW SAXON, M.D.; RONALD H. STEVENS, Ph.D.; DAVID W. GOLDE, M.D., F.A.C.P.
Immunohematologic studies on cells from a patient with the clinicopathologic syndrome of hairy-cell leukemia showed that the neoplastic cells had receptors for sheep erythrocytes and therefore had human-T-lymphocyte characteristics. The leukemic cells did not have the membrane receptors or immunoglobulin markers of B lymphocytes or monocytes nor did they synthesize immunoglobulin. A lymphoid cell line established in vitro from the cells had the same T-lymphocyte characteristics. The lymphoid cell line is positive for tartrateresistant acid phosphatase, forms rosettes with untreated sheep erythrocytes, and reacts with an anti-T-lymphocyte antiserum. Thus the syndrome of hairy-cell leukemia may occasionally result from the neoplastic proliferation of T lymphocytes as well as from the more usual B-lymphocyte form. This situation is analogous to that described previously in chronic lymphocytic leukemia and other lymphoproliferative disorders.
ANDREW SAXON, RONALD H. STEVENS, DAVID W. GOLDE. T-Lymphocyte Variant of Hairy-Cell Leukemia. Ann Intern Med. 1978;88:323–326. doi: 10.7326/0003-4819-88-3-323
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Published: Ann Intern Med. 1978;88(3):323-326.
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