DANIEL KORDANSKY, M.D.; N. FRANKLIN ADKINSON Jr., M.D.; PHILIP S. NORMAN, M.D.; RICHARD R. ROSENTHAL, M.D.
A patient who claimed benefit from aspirin for her reversible bronchospasm was challenged orally in a placebo-controlled study with aspirin and other aspirin-like drugs. Specific airways conductance and spirometry were monitored for up to 150 minutes after oral challenge. Aspirin, mefenamic acid, and ibuprofen administration resulted in marked (45% to 80%) improvement in forced expiratory volume in 1 second (FEV1) compared to lactose placebo. Indomethacin, sodium salicylate, and tartrazine resulted in modest (15% to 25%) FEV1 improvement, while phenylbutazone produced a 25% decrease. These results are discussed here in terms of the ability of these drugs to inhibit the prostaglandin synthetase enzyme system. This case suggests that aspirin and other nonsteroidal anti-inflammatory drugs may be beneficial rather than harmful in some asthmatic patients.
DANIEL KORDANSKY, N. FRANKLIN ADKINSON, PHILIP S. NORMAN, RICHARD R. ROSENTHAL. Asthma Improved by Nonsteroidal Anti-Inflammatory Drugs. Ann Intern Med. 1978;88:508–511. doi: 10.7326/0003-4819-88-4-508
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Published: Ann Intern Med. 1978;88(4):508-511.
Asthma, Pulmonary/Critical Care.
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