CARL LAWYER, M.D.; JACK AITCHISON, Ph.D.; JAMES SUTTON, M.D.; WILLIAM BENNETT, M.D., F.A.C.P.
High plasma concentrations of theophylline may be associated with seizures (1). Patients who manifest such seizures often have liver disease. The seizures are often refractory to intravenous diazepam, phenytoin, and phenobarbital. Mortality from theophylline neurotoxicity is high. Indeed, Zwillich and co-workers (1) reported a 50% mortality in their series of eight patients. Resin hemoperfusion, although proven effective in barbiturate overdoses (2), has not been previously used for treatment of theophylline neurotoxicity.
A 50-year-old white woman with chronic alcoholism was hospitalized because of jaundice and increasing ascites. She had previously received various theophylline preparations for episodic asthma. Physical findings at admission
LAWYER C, AITCHISON J, SUTTON J, BENNETT W. Treatment of Theophylline Neurotoxicity with Resin Hemoperfusion. Ann Intern Med. ;88:516–517. doi: 10.7326/0003-4819-88-4-516
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Published: Ann Intern Med. 1978;88(4):516-517.
Emergency Medicine, Neurology.
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