J. W. MAAS, M.D.
Indirect evidence, mostly pharmacologic, has suggested a role for brain neurotransmitter amines such as norepinephrine in the production of depression or mania. Clinical investigations have supported this concept but also indicate that depression is probably a biochemically heterogeneous group of illnesses. There may be a clinically, biochemically, and pharmacologically definable subtype of depression in which there is a disorder of norepinephrine metabolism or disposition in brain. I review here the experimental data from which this hypothesis is derived.
MAAS JW. Clinical and Biochemical Heterogeneity of Depressive Disorders. Ann Intern Med. ;88:556–563. doi: 10.7326/0003-4819-88-4-556
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Published: Ann Intern Med. 1978;88(4):556-563.
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