L. M. LEHRNER, PH.D., M.D.; ROBERT E. ENCK, M.D.
To the editor: Recently, combination chemotherapy with cytarabine and 6-thioguanine has been associated with the development of hepatic veno-occlusive disease (hepatic-vein thrombosis, Budd-Chiari syndrome) (1, 2). We wish to report a case of retroperitoneal malignant fibrous histiocytoma in which hepatic-vein thrombosis developed after combination chemotherapy with doxorubicin, dacarbazine, vincristine, and cyclophosphamide.
A 46-year-old white man underwent an exploratory laparotomy for diagnosis of an abdominal mass. At surgery, an unresectable malignant fibrous histiocytoma was found between the leaves of the small-bowel mesentery. One month later, the first course of chemotherapy was administered and was followed in 3 weeks by a second
LEHRNER LM, ENCK RE. Hepatic-Vein Thrombosis After Chemotherapy for Histiocytoma. Ann Intern Med. ;88:575–576. doi: 10.7326/0003-4819-88-4-575_2
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Published: Ann Intern Med. 1978;88(4):575-576.
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