TREVOR R.P. PRICE, M.D.; PAUL J. BEISSWENGER, M.D.
To the editor: Although mild polyuria (>3 litres/day) and polydipsia are quite common (12% and 40%, respectively) with lithium carbonate therapy (1, 2), nephrogenic diabetes insipidus is an uncommon complication first recognized in the early 1970s (3). In reported cases marked polyuria and polydipsia have variably appeared between the second week and seventh month after the start of therapy and have gradually increased to maximum severity over the next 1 to 3 weeks. The reported cases have generally occurred with nontoxic serum lithium concentrations and have been associated with laboratory evidence of nephrogenic diabetes insipidus, which generally clears within 3
PRICE TR, BEISSWENGER PJ. Lithium and Diabetes Insipidus. Ann Intern Med. ;88:576–577. doi: 10.7326/0003-4819-88-4-576_2
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Published: Ann Intern Med. 1978;88(4):576-577.
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