STEPHEN A. KLOTZ, M.D.; BILLY F. KAY, M.D.
To the editor: The following two case histories describe apparent adverse reactions to the histamine H2-receptor antagonist cimetidine (Tagamet®).
A 62-year-old woman with a complicated medical history that included an autoimmune thrombocytopenia (with antiplatelet antibodies) and arthritis and pleural effusion (with the absence of antinuclear antibodies, rheumatoid factor, or lupus erythematosus cell phenomenon) had been taking cimetidine, 300 mg four times daily for 1 month, for endoscopically proven severe antral gastritis and a bezoar. Concurrent medications included hydrochlorothiazide, 50 mg every day; propranolol, 20 mg three times daily; Synthroid®, 0.1 mg every day; and prednisone, 10 and 5 mg on
KLOTZ SA, KAY BF. Cimetidine and Agranulocytosis. Ann Intern Med. ;88:579–580. doi: 10.7326/0003-4819-88-4-579_2
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Published: Ann Intern Med. 1978;88(4):579-580.
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