NORMAN G. SCHNEEBERG, M.D.
To the editor: The ubiquity of postradiation hypothyroidism after treatment of Graves' disease with 131I has fostered various attempts to thwart this complication. The most fashionable approach today is to substantially reduce the dose of 131I. The result has been a lower incidence of hypothyroidism. For example, Smith and Wilson (1) lowered the conventional dose of 7000 rad to 3500 rad and reduced hypothyroidism from 29% to 5% in the first 5 years of follow-up. The smaller dose, however, frequently delays cure of hyperthyroidism and necessitates the use of an antithyroid drug or propanolol during the toxic interval.
SCHNEEBERG NG. 131I Dosage. Ann Intern Med. ;88:580. doi: 10.7326/0003-4819-88-4-580_1
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Published: Ann Intern Med. 1978;88(4):580.
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