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Lupus erythematosus is an unusually complex disorder. Its clinical features extend into every system and most organs of the body. Moreover, the disease is expressed selectively rather than uniformly from patient to patient. In most patients only three, four or perhaps five organs are involved. Some, of course, have more widespread involvement. Others have only one or two systems involved. Thus, the recognition, diagnosis, and treatment can be most challenging to clinicians, and etiology and pathophysiology an even greater challenge to investigators. Lupus erythematosus has strong ties to immune function. These ties may concern the most central of issues: etiology.
Lupus Erythematosus.. Ann Intern Med. 1978;88:583–584. doi: 10.7326/0003-4819-88-4-583_3
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Published: Ann Intern Med. 1978;88(4):583-584.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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