ROBERT L. WOLLMUTH, M.D.; JAMES B. WAGONFELD, M.D.
To the editor: Deveney and associates have convincingly demonstrated the usefulness of the secretin test in the diagnosis of the Zollinger-Ellison syndrome. They note that a rise in serum gastrin of 110 pg/ml in response to secretin "should produce no false-positive responses" (1). Doctor Ippoliti, in his editorial, reports that he has seen no false-positive responses to secretin (2). We wish to report such a false-positive response in a young woman with achlorhydria and hypergastrinemia.
A 28-year-old woman had a 2-year history of postprandial abdominal cramps, followed by loose watery stools. Her history and physical findings were otherwise unremarkable. Evaluation
WOLLMUTH RL, WAGONFELD JB. False-Positive Secretin Test. Ann Intern Med. ;88:718–719. doi: 10.7326/0003-4819-88-5-718_2
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Published: Ann Intern Med. 1978;88(5):718-719.
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