DAL YOO, M.D.; LAWRENCE S. LESSIN, M.D.; WALLACE N. JENSEN, M.D.
Increased bone-marrow mast-cell content and lymphoproliferative disorders have been previously linked. Using a semiquantitative method we examined bone-marrow mast-cell content in 120 marrow specimens from patients with multiple myeloma, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and reactive lymphocytosis. Results indicated a statistically significant increase of marrow mast-cell content in patients with chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and reactive lymphocytosis when compared with iron-deficient control subjects (p ≤ 0.0005). Patients with multiple myeloma had decreased marrow mast-cell content, clearly separating them from patients with lymphoproliferative disorders and reactive lymphocytosis. Linear regression plot of marrow mast-cell content against percentage of marrow lymphocytes showed a direct relation, indicating that marrow mast-cell density may be related more to the degree of lymphoid proliferation than to the specific lymphoproliferative process. Marrow mast-cell content may therefore be reproducibly determined and used to support the morphologic diagnosis of lymphoproliferative disorders and differentiate them from atypical myelomas.
DAL YOO, LAWRENCE S. LESSIN, WALLACE N. JENSEN. Bone-Marrow Mast Cells in Lymphoproliferative Disorders. Ann Intern Med. 1978;88:753–757. doi: 10.7326/0003-4819-88-6-753
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Published: Ann Intern Med. 1978;88(6):753-757.
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