NEIL H. SHUSTERMAN, B.S.; CHRIS FRAUENHOFFER, M.D.; M. DEAN KINSEY, M.D.
Cytomegalovirus Mononucleosis is an acute febrile illness characterized by atypical lymphocytosis (1). The clinical picture strikingly resembles infectious mononucleosis with generalized malaise and splenomegaly. Persistently negative heterophil-antibody tests are an important laboratory finding in distinguishing this syndrome from Epstein-Barr virus-induced infectious mononucleosis.
Hepatic involvement is a common finding in cytomegalovirus mononucleosis as manifested by mild hepatomegaly, consistent increases in serum transaminase activity, and variable elevation of serum alkaline phosphatase and bilirubin. We present here a case of fatal massive hepatic necrosis in a patient with cytomegalovirus mononucleosis.
A 33-year-old previously healthy man had a 2-week history of fever, malaise, night
SHUSTERMAN NH, FRAUENHOFFER C, KINSEY MD. Fatal Massive Hepatic Necrosis in Cytomegalovirus Mononucleosis. Ann Intern Med. ;88:810–812. doi: 10.7326/0003-4819-88-6-810
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Published: Ann Intern Med. 1978;88(6):810-812.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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