ALLAN ELLSWORTH, PHARM.D.; DAVID BROWN, PHARM.D.
To the editor: LeLorier and associates (Ann Intern Med 87:700-702, 1977) support the observation made by others that the half-life of lidocaine is increased after discontinuation of infusions lasting more than 24 h in patients with uncomplicated myocardial infarction (1, 2). As the authors pointed out, lidocaine clearance has been shown to correlate well with cardiac index and hepatic blood flow (3, 4). While the study attempted to show increased lidocaine half-life in patients without renal, hepatic, or heart failure, it must be pointed out that a decreased cardiac index and hepatic failure have not been ruled out by their
ELLSWORTH A, BROWN D. Lidocaine Clearance. Ann Intern Med. ;88:847. doi: 10.7326/0003-4819-88-6-847_1
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Published: Ann Intern Med. 1978;88(6):847.
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