OSCAR D. RATNOFF, M.D.; PAUL K. JONES, PH.D.
Classic hemophilia is a rare disease and Christmas disease, rarer still. These two disorders are essentially limited to males, in whom the bleeding propensity is roughly proportional to the degree of deficiency of antihemophilic factor (AHF, factor VIII) or Christmas factor (factor IX), as measured in assays of clotting function. The female relatives of these bleeders are ordinarily asymptomatic, but some may transmit the bleeding tendency to their sons.
For many reasons, classic hemophilia and Christmas disease have evoked a disproportionate interest among physicians; one such reason may be a fascination with the peculiar pattern of inheritance, a pattern that
RATNOFF OD, JONES PK. The Art of Betting: Which of a Bleeder's Female Relatives Is a Carrier?. Ann Intern Med. ;89:281–282. doi: 10.7326/0003-4819-89-2-281
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Published: Ann Intern Med. 1978;89(2):281-282.
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