E. NEIL SCHACHTER, M.D.; HARVEY KREISMAN, M.D.; AREND BOUHUYS, M.D.
To the editor: Kordansky and associates (Ann Intern Med 88:508-511, 1978) present a unique, well-documented case of an adult with nonatopic, adult-onset asthma whose bronchospasm improved after the administration of well-established prostaglandin-synthesis inhibitor drugs (aspirin, mefenamic acid, Ibuprofen). Idiosyncratic findings such as these, as well as in-vitro studies on the influence of prostaglandin-synthesis inhibitors on smooth muscle, have led some authors to postulate a fundamental role for prostaglandins in asthma (1). To guard against the uncontrolled use of such ubiquitous drugs as prostaglandin-synthesis inhibitors in a population known to have a high degree of aspirin intolerance (2), we wish to
E. NEIL SCHACHTER, HARVEY KREISMAN, AREND BOUHUYS. Prostaglandin-Synthesis Inhibition and Exercise Bronchospasm. Ann Intern Med. 1978;89:287–288. doi: 10.7326/0003-4819-89-2-287_2
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Published: Ann Intern Med. 1978;89(2):287-288.
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