C. VENKATA S. RAM, M.D.; MICHAEL J. REICHGOTT, M.D., PH.D.
To the editor: In their discussion of resistant hypertension in a recent issue (1), Drs. Gifford and Tarazi state that fluid retention accompanying minoxidil treatment is "barely controllable" by diuretics in "high doses." This point may be somewhat overstated. While minoxidil undoubtedly causes a severe degree of fluid retention, this side effect can in most instances be controlled with appropriate doses of a loop-diuretic alone or by the addition of metolazone (2, 3) in conjunction with dietary restriction of sodium intake.
RAM CVS, REICHGOTT MJ. Fluid Retention with Minoxidil. Ann Intern Med. ;89:288–289. doi: 10.7326/0003-4819-89-2-288_3
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Published: Ann Intern Med. 1978;89(2):288-289.
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