HERBERT E. COHEN, M.D., F.A.C.P.
To the editor: The observation that rheumatoid factors may reflect the immune nature of Graves' disease (1) is of interest, but unfortunately the authors did not consider the even more provocative inverse implications of their results on the causality of rheumatoid arthritis. The negative disease interaction between hyperthyroidism and rheumatoid arthritis is not generally appreciated, but clinical rheumatoid arthritis is uncommon in the presence of hyperthyroidism, and treatment of hyperthyroidism occasionally precipitates an acute attack of rheumatoid arthritis. The fact that hyperthyroid suppression of rheumatoid arthritis occurs in the presence of serum titers of rheumatoid factors is unexpected and worthy
HERBERT E. COHEN. Rheumatoid Arthritis in Hyperthyroidism. Ann Intern Med. 1978;89:290. doi: 10.7326/0003-4819-89-2-290
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Published: Ann Intern Med. 1978;89(2):290.
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